{"id":58670,"date":"2024-03-14T15:35:51","date_gmt":"2024-03-14T14:35:51","guid":{"rendered":"https:\/\/dignitynews.eu\/?p=58670"},"modified":"2024-03-14T15:35:51","modified_gmt":"2024-03-14T14:35:51","slug":"polscy-badacze-wykorzystuja-modele-ludzkie-w-badaniach-nad-choroba-huntingtona","status":"publish","type":"post","link":"https:\/\/dignitynews.eu\/pl\/polscy-badacze-wykorzystuja-modele-ludzkie-w-badaniach-nad-choroba-huntingtona\/","title":{"rendered":"Polscy badacze wykorzystuj\u0105 modele ludzkie w badaniach nad chorob\u0105 Huntingtona"},"content":{"rendered":"<h5><strong>Naukowcy z Centrum Nauk o \u017byciu i Biotechnologii w \u0141ukasiewicz \u2013 PORT pracuj\u0105 nad terapiami, kt\u00f3re mog\u0105 przyczyni\u0107 si\u0119 do prze\u0142omu w leczeniu powa\u017cnych schorze\u0144. Przedmiotem bada\u0144 dr Agnieszki Krzy\u017cosiak i prowadzonej przez ni\u0105 Grupy Badawczej Mechanizm\u00f3w Neurodegeneracji jest innowacyjne podej\u015bcie do leczenia choroby Huntingtona. <\/strong><\/h5>\n<p>Choroba Huntingtona to rzadka genetyczna choroba neurodegeneracyjna, na kt\u00f3r\u0105, wedle szacunk\u00f3w, choruje 5 na 100 000 os\u00f3b. W miar\u0119 rozwoju choroby do jej najpowa\u017cniejszych objaw\u00f3w nale\u017c\u0105 nieskoordynowane, mimowolne ruchy, problemy motoryczne, objawy emocjonalne, takie jak depresja oraz zaburzenia funkcji poznawczych.<\/p>\n<p>Jest to najcz\u0119stsza choroba neurodegeneracyjna, za kt\u00f3rej wyst\u0105pienie odpowiada tylko jeden czynnik genetyczny. Bezpo\u015bredni\u0105 przyczyn\u0105 choroby jest ekspansja \u0142a\u0144cucha poliglutaminowego w bia\u0142ku huntingtynie, kt\u00f3ra prowadzi do agregacji tego bia\u0142ka, a co za tym idzie \u2013 szeregu dysfunkcji w kom\u00f3rce, deregulacji proteostazy kom\u00f3rkowej oraz ostatecznie \u2013 \u015bmierci kom\u00f3rkowej, tzn. \u015bmierci neuron\u00f3w w m\u00f3zgu.<\/p>\n<p>Do najwi\u0119kszych czynnik\u00f3w ryzyka choroby zalicza si\u0119 wiek (35-50 lat).<\/p>\n<p>W swoich pracach badamy podstawy molekularne choroby Huntingtona, skupiamy si\u0119 przede wszystkim na procesach kontroli jako\u015bci bia\u0142ek w celu lepszego zrozumienia procesu akumulacji huntingtyny w kom\u00f3rce\u00a0\u2013 wyja\u015bnia dr Agnieszka Krzy\u017cosiak, liderka Grupy Badawczej Mechanizm\u00f3w Neurodegeneracji w \u0141ukasiewicz \u2013 PORT. Nasze wcze\u015bniejsze badania potwierdzi\u0142y, \u017ce kom\u00f3rka, w kt\u00f3rej farmakologicznie wzmocniona zosta\u0142a proteostaza kom\u00f3rkowa, potrafi lepiej radzi\u0107 sobie z procesem agregacji bia\u0142ka chorobotw\u00f3rczego. Wiedz\u0105c, \u017ce to podej\u015bcie, czyli celowanie w procesy kontroli jako\u015bci bia\u0142ek, jest skuteczne, poszukujemy aktualnie nowych cel\u00f3w terapeutycznych\u00a0\u2013 dodaje dr Agnieszka Krzy\u017cosiak.<\/p>\n<p>Tym, co stanowi innowacj\u0119 w badaniach nad chorob\u0105 Huntingtona w \u0141ukasiewicz \u2013 PORT, jest wykorzystanie w badaniach modeli ludzkich pochodz\u0105cych od pacjent\u00f3w, jako alternatywy dla modeli zwierz\u0119cych.<\/p>\n<p>Adrian Andrzejewski<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Naukowcy z Centrum Nauk o \u017byciu i Biotechnologii w \u0141ukasiewicz \u2013 PORT pracuj\u0105 nad terapiami, kt\u00f3re mog\u0105 przyczyni\u0107 si\u0119 do prze\u0142omu w leczeniu powa\u017cnych schorze\u0144. Przedmiotem bada\u0144 dr Agnieszki Krzy\u017cosiak&hellip;<\/p>\n","protected":false},"author":7,"featured_media":58671,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"footnotes":""},"categories":[60],"tags":[],"class_list":["post-58670","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-60"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Polscy badacze wykorzystuj\u0105 modele ludzkie w badaniach nad chorob\u0105 Huntingtona - Godno\u015b\u0107 - DignityNews.eu<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dignitynews.eu\/pl\/polscy-badacze-wykorzystuja-modele-ludzkie-w-badaniach-nad-choroba-huntingtona\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Polscy badacze wykorzystuj\u0105 modele ludzkie w badaniach nad chorob\u0105 Huntingtona - Godno\u015b\u0107 - DignityNews.eu\" \/>\n<meta property=\"og:description\" content=\"Naukowcy z Centrum Nauk o \u017byciu i Biotechnologii w \u0141ukasiewicz \u2013 PORT pracuj\u0105 nad terapiami, kt\u00f3re mog\u0105 przyczyni\u0107 si\u0119 do prze\u0142omu w leczeniu powa\u017cnych schorze\u0144. 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